Emmanuel Stip

Axe de recherche

• Traitement et réadaptation adaptés aux populations 
• Développement technologique et transfert des connaissances

Affiliation universitaire (poste ou fonction)

Directeur
Département de psychiatrie
Faculté de médecine
Université de Montréal

Titulaire
Chaire Eli Lilly Canada de recherche en schizophrénie
Université de Montréal

Profil

Emmanuel Stip s'intéresse depuis plusieurs années aux effets des antipsychotiques sur la cognition (neuropsychologie) dans la schizophrénie.  En collaboration avec Adrianna Mendrek et Lahcen Ait Bentaleb (chercheur associé), il utilise les techniques d'imagerie cérébrale (RMf) pour étudier les corrélats cérébraux de ces variables cognitives.

Prix et distinctions

• Chercheur boursier junior 2 du FRSQ Fonds de la Recherche en Santé du Québec (FRSQ)

Publications récentes

Lungu, O., Barakat, M.,Laventure, S., Debas, K., Proulx, S., Luck, D., Stip, E. (2012). The Incidence and Nature of Cerebellar Findings in Schizophrenia: A Quantitative Review of fMRI Literature. Schizophr Bull.  Pubmed

Dumais, A., Potvin, S., Joyal, C., Allaire, J. F., Stip, E., Lesage, A., Gobbi, G., Cote, G. (2011). Schizophrenia and serious violence: A clinical-profile analysis incorporating impulsivity and substance-use disorders. Schizophrenia research. 130(1-3), 234-237. Pubmed

Guillaume, F., Guillem, F., Tiberghien, G., & Stip, E. (2011). ERP investigation of study-test background mismatch during face recognition in schizophrenia. Schizophrenia Research, 134(1), 101-109. Pubmed

Homayoun, S., Nadeau-Marcotte, F., Luck, D., & Stip, E. (2011). Subjective and Objective Cognitive Dysfunction in Schizophrenia - is there a Link? Frontiers in psychology, 2, 148. Pubmed

Honer, W. G., Macewan, G. W., Gendron, A., Stip, E., Labelle, A., Williams, R., Eriksson, H. (2011). A randomized, double-blind, placebo-controlled study of the safety and tolerability of high-dose quetiapine in patients with persistent symptoms of schizophrenia or schizoaffective disorder. The Journal of clinical psychiatry. Pubmed

Igue, R., Potvin, S., Bah, R., Stip, E., Bouchard, R. H., Lipp, O., Gendron, A. Kouassi, E. (2011). Soluble interleukin-2 receptor levels correlated with positive symptoms during quetiapine treatment in schizophrenia-spectrum disorders. Progress in neuro-psychopharmacology & biological psychiatry, 35(7), 1695-1698. Pubmed

Lakis, N., Jimenez, J. A., Mancini-Marie, A., Stip, E., Lavoie, M. E., & Mendrek, A. (2011). Neural correlates of emotional recognition memory in schizophrenia: Effects of valence and arousal. Psychiatry Research, 194(3), 245-256. Pubmed

Lavoie, M. E., Imbriglio, T. V., Stip, E., & O'Connor, K. P. (2011). Neurocognitive Changes Following Cognitive-Behavioral Treatment in Tourette Syndrome and Chronic Tic Disorder. International Journal of Cognitive Therapy, 4(1), 34-50. Résumé

Letourneau, G., & Stip, E. (2011). Plea to estabilish a registry of clinical trials on cognitive-behavioural therapies and cognitive remediation. The Canadian Journal of Psychiatry / La Revue canadienne de psychiatrie, 56(3), 189. Pubmed

Stip, E., Zhornitsky, S., Moteshafi, H., Letourneau, G., Stikarovska, I., Potvin, S., Tourjman, V. (2011). Ziprasidone for psychotic disorders: a meta-analysis and systematic review of the relationship between pharmacokinetics, pharmacodynamics, and clinical profile. Clinical Therapeutics, 33(12), 1853-1867. Pubmed

Stip, E., Abdel-Baki, A., Bloom, D., Grignon, S., & Roy, M. A. (2011). Les antipsychotiques injectables à action prolongée : avis d’experts de l’Association des médecins psychiatres du Québec. Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie, 56(6), 367-376. Résumé ou article pas disponible

Zhornitsky, S., Potvin, S., Moteshafi, H., Dubreucq, S., Rompre, P. P., & Stip, E. (2011). Dose-response and comparative efficacy and tolerability of quetiapine across psychiatric disorders: a systematic review of the placebo-controlled monotherapy and add-on trials. International clinical psychopharmacology, 26(4), 183-192. Pubmed

Zhornitsky, S., Potvin, S. P., Aubin, G., & Stip, E. (2011). Relationship between insight into cognition, extrapyramidal symptoms and mental illness in schizophrenia. The Australian and New Zealand journal of psychiatry. Pubmed

Briand, C., Reinharz, D., Lesage, A., Nicole, L., Stip, E., Lalonde, P., Villeneuve, K., Planet-Sultan, S. (2010). L’implantation au Québec de l’Integrated Psychological Treatment (IPT) auprès des personnes atteintes de schizophrénie : cinq ans après. Sante mentale au Quebec, 35(2), 145-162. Pubmed

Desfosses, J., Stip, E., Bentaleb, L. A., & Potvin, S. (2010). Endocannabinoids and schizophrenia. [Review]. Pharmaceuticals, 3 (10), 3101-3126.

Lecardeur, L., Stip, E., & Champagne-Lavau, M. (2010). Cognitive remediation therapy of social cognition in schizophrenia: A critical review. Current Psychiatry Reviews, 6 (4), 280-287. Pas dans Pubmed

Rizkallah, E., Stip, E., Zhornitsky, S., Pampoulova, T., Gendron, A., Rompre, P. P., et al. (2010). Clinical evolution of substance use disorder patients during treatment with quetiapine: a 12-week, open-label, naturalistic trial. Expert opinion on pharmacotherapy. Pubmed

Zhornitsky, S., Potvin, S., Stip, E. Rompre, P.-P. (2010). Acute quetiapine dose-dependently exacerbates anhedonia induced by withdrawal from escalating doses of D-amphetamine. European Neuropsychopharmacology. 20(10), 695-703. Pubmed

Poulin, J., Chouinard, S., Pampoulova, T., Lecomte, Y., Stip, E., & Godbout, R. (2010). Sleep habits in middle-aged, non-hospitalized men and women with schizophrenia: A comparison with healthy controls. Psychiatry research. 179(3), 274-278. Pubmed

Stip, E., Zhornitsky, S., Potvin, S., & Tourjman, V. (2010). Switching from conventional antipsychotics to ziprasidone: A randomized, open-label comparison of regimen strategies. Progress in neuro-psychopharmacology & biological psychiatry, 34(6), 997-1000. Pubmed

Zhornitsky, S., Rizkallah, E., Pampoulova, T., Chiasson, J. P., Stip, E., Rompre, P. P., Potvin, S., et al. (2010). Antipsychotic agents for the treatment of substance use disorders in patients with and without comorbid psychosis. Journal of clinical psychopharmacology, 30(4), 417-424. Pubmed

Zhornitsky, S., Stip, E., Pampoulova, T., Rizkallah, E., Lipp, O., Bentaleb, L. A., Chiasson, J. P., Potvin, S., (2010). Extrapyramidal symptoms in substance abusers with and without schizophrenia and in nonabusing patients with schizophrenia. Movement disorders : official journal of the Movement Disorder Society, 25(13), 2188-2194. Pubmed

Zhornitsky, S., Potvin, S. P., Aubin, G., & Stip, E. (2011). Relationship between insight into cognition, extrapyramidal symptoms and mental illness in schizophrenia. The Australian and New Zealand journal of psychiatry, 45(7), 604-605. Pubmed

Mendrek, A., Jimenez, J. A., Mancini-Marie, A., Fahim, C., & Stip, E. (2010). Correlations between sadness-induced cerebral activations and schizophrenia symptoms: An fMRI study of sex differences. European psychiatry. 26(5), 320-326. Pubmed

Stip, E., Tourjman, V. (2010) Aripiprazole in Schizophrenia and Schizoaffective Disorder: A Review. Clinical Therapeutics, 32, S3-S20. Pubmed

Champagne-Lavau, M., & Stip, E. (2010) Pragmatic and executive dysfunction in schizophrenia. Journal of Neurolinguistics, 23(3), 285-296.

Lecardeur, L., Mendrek, A., & Stip, E. (2010) Sexual dimorphism of spatial working memory profiles in schizophrenia. Cognitive neuropsychiatry, 15(4), 397-405. Pubmed

Guillem, F., Pampoulova, T., Rinaldi, M., & Stip, E. (2009). Temperament and executive dysfunctions in schizophrenia. Schizophrenia Research, 104(1-3), 175-184. Pubmed  

Guillem, F., Mendrek, A., Lavoie, M. E., Pampoulova, T., & Stip, E. (2009). Sex differences in memory processing in schizophrenia: An event-related potential (ERP) study. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33(1), 1-10.

Guillem, F., Satterthwaite, J., Pampoulova, T., & Stip, E. (2009). Relationship between psychotic and obsessive compulsive symptoms in schizophrenia. Schizophrenia Research, 115(2-3), 358-362. Pubmed

Lecardeur, L., Briand, C., Prouteau, A., Lalonde, P., Nicole, L., Lesage, A., Stip, E., et al. (2009). Preserved awareness of their cognitive deficits in patients with schizophrenia: Convergent validity of the SSTICS. Schizophrenia Research, 107(2-3), 303-306.

Lecardeur, L., Stip, E., Giguere, M., Blouin, G., Rodriguez, J., & Champagne-Lavau, M. (2009). Effects of cognitive remediation therapies on psychotic symptoms and cognitive complaints in patients with schizophrenia and related disorders: a randomized study. Schizophrenia Research, 111(1-3), 153-158.Pubmed 

Mancini-Marie, A., Cohen-Adad, J., Jimenez, J., Corcoran, C., Rainville, P., Stip, E., et al. (2009). Sex Differences in Corpus Callosum Fractional Anisotropy in Schizophrenia Patients: a Pilot Tractography Study Using Diffusion Tensor Imaging. Schizophrenia Bulletin, 35, 210-211.

O'Connor, K., Laverdure, A., Taillon, A., Stip, E., Borgeat, F., & Lavoie, M. (2009). Cognitive behavioral management of Tourette's syndrome and chronic tic disorder in medicated and unmedicated samples. Behaviour Research and Therapy, 47(12), 1090-1095. Pubmed 

Potvin, S., Blanchet, P., & Stip, E. (2009). Substance abuse is associated with increased extrapyramidal symptoms in schizophrenia: A meta-analysis. Schizophrenia Research, Jul. 14(Epub ahead of print). Pubmed  

Sablier, J., Stip, E., & Franck, N. (2009). Remediation cognitive et assistants cognitifs numeriques dans la schizophrenie. L'Encéphale, 35(2), 160-167.Pubmed

Simon, A. E., Lester, H., Tait, L., Stip, E., Roy, P., Conrad, G., et al. (2009). The International Study on General Practitioners and Early Psychosis (IGPS). Schizophrenia Research, 108(1-3), 182-190.

Stip, E. (2009). Le regard du psychiatre canadien. L'Encéphale, 35(Suppl. 3), S115-S118. Pubmed 

Stip, E. (2009). Rôles des médecins de famille dans le traitement des troubles psychotiques. Santé mentale au Québec, 34(1), 173-178. Pubmed

Stip, E. (2009). Psychosis: A Category or a Dimension? Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie, 54(3), 137-139.

Stip, E., & Letourneau, G. (2009). Psychotic Symptoms as a Continuum Between Normality and Pathology. Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie, 54(3), 140-151.

Stip, E., Mancini-Marie, A., Letourneau, G., Fahim, C., Mensour, B., Crivello, F., et al. (2009). Increased grey matter densities in schizophrenia patients with negative symptoms after treatment with quetiapine: a voxel-based morphometry study. International Clinical Psychopharmacology, 24(1), 34-41.

Guillem, F., Pampoulova, T., Rinaldi, M., & Stip, E. (2008). Temperament and executive dysfunctions in schizophrenia. Schizophrenia Research, 104(1-3), 175-184.

Guillem, F., Rinaldi, M., Parnpoulova, T., & Stip, E. (2008). The complex relationships between executive functions and positive symptoms in schizophrenia. Psychological Medicine, 38(6), 853-860.

O'Connor, K. P., Lavoie, M. E., Stip, E., Borgeat, F., & Laverdure, A. (2008). Cognitive-behaviour therapy and skilled motor performance in adults with chronic tic disorder. Neuropsychological Rehabilitation, 18(1), 45-64.

Potvin, S., Joyal, C. C., Pelletier, J., & Stip, E. (2008). Contradictory cognitive capacities among substance-abusing patients with schizophrenia: A meta-analysis. Schizophrenia Research, 100(1-3), 242-251.

Potvin, S., Kouassi, E., Lipp, O., Bouchard, R. H., Roy, M. A., Demers, M. F., Stip, E., et al. (2008). Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy. Journal of Psychopharmacology, 22(3), 262-269.

Potvin, S., Stip, E., Lipp, O., Roy, M. A., Demers, M. F., Bouchard, R. H., et al. (2008). Anhedonia and social adaptation predict substance abuse evolution in dual diagnosis schizophrenia. American Journal of Drug and Alcohol Abuse, 34(1), 75-82.

Potvin, S., Stip, E., Sepehry, A. A., Gendron, A., Bah, R., & Kouassi, E. (2008). Inflammatory cytokine alterations in schizophrenia: A systematic quantitative review. Biological Psychiatry, 63(8), 801-808.

Potvin, S., Stip, E., Templer, A., Pampoulova, T., Bentaleb, L. A., Lalonde, P., et al. (2008). Pain perception in schizophrenia: No changes in diffuse noxious inhibitory controls (DNIC) but a lack of pain sensitization. Journal of Psychiatric Research, 42(12), 1010-1016.

Poulin, J., Stip, E., & Godbout, R. (2008). REM sleep EEG spectral analysis in patients with first-episode schizophrenia. Journal of Psychiatric Research, 42(13), 1086-1093.

Sengupta, S., Parrilla-Escobar, M. A., Klink, R., Fathalli, F., Ng, Y. K., Stip, E., et al. (2008). Are metabolic indices different between drug-naive first-episode psychosis patients and healthy controls? Schizophrenia Research, 102(1-3), 329-336.

Stip, E., Mancini-Marie, A., Fahim, C., Bentaleb, L. A., Letourneau, G., & Potvin, S. (2008). Decrease in basal ganglia grey matter density associated with atypical antipsychotic treatment in schizophrenia patients. Schizophrenia Research, 103(1-3), 319-321.

Thibault, G., Felezeu, M., O'Connor, K. P., Todorov, C., Stip, E., & Lavoie, M. E. (2008). Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 32(3), 803-815.

Tranulis, C., Sepehry, A. A., Galinowski, A., & Stip, E. (2008). Should we treat auditory hallucinations with repetitive transcranial magnetic stimulation? A metaanalysis. Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie, 53(9), 577-586

Champagne-Lavaux, M., Stip, E. et al. (2007). " Language Functions in Right-Hemisphere Damage and Schizophrenia: Apparently Similar Pragmatic Deficits May Hide Profound Differences." Brain and Cognition 130(2): 67.

Chouinard, S., Sepehry, A., Stip, E., et al. (2007). "Oral Cholinesterase Inhibitor Add-On Therapy for Cognitive Enhancement in Schizophrenia: A Quantitative Systematic Review, Part I." Clin Neuropharmacol. 30(3): 169-182.

Chouinard, S., Stip, E., et al. (2007). "Rivastigmine Treatment as an Add-On to Antipsychotics in Patients with Schizophrenia and Cognitive Deficits." Current Medical Research and Opinion(23): 575-583.

Fahim, C., Stip, E., et al. (2007). "Orbitofrontal Dysfunctionning in a Monozygotic Twin Discordant for Post-Partum Affective Psychosis: a fMRI Case Study." Bipolar disorder 5: 541-545.

Forest, G., Poulin, J., Stip, E., et al. (2007). "Attention and Non-REM Sleep in Neuroleptic-Naive Persons with Schizophrenia and Control Participants." Psychiatry Research (149): 33- 40.

Joyal, C. C., Putkonen, A., Stip, E., et al. (2007). "Violent Offenders with Schizophrenia and Comorbid Disorders: A Functional Magnetic Resonance Imaging Study." Schizophrenia Research 91: 97-102.

Lavoie, M., G. Thibault, Stip, E., et al. (2007). "Memory and Executive Functions in Adults with Gilles de la Tourette Syndrome and Chronic Tic Disorder." Cognitive Neuropsychiatry 12(2): 165-181.

Lecardeur, L., B. Giffard, Stip, E., et al. (2007). "Does Hyperpriming Reveal Impaired Spreading of Activation in Schizophrenia?" Schizophrenia Research 97(1-3):289-91.

Levaux, M. N., Potvin, S., Stip, E., et al. (2007). "Cognitive Assessment in Schizophrenia: Promises and Pitfalls of CANTAB." European Psychiatry 22(2):104-115.

Mendrek, A., Mancini-Marie, A., Stip, E., et al. (2007). "Sex Differences in the Cerebral Function Associated with Processing of Aversive Stimuli by Schizophrenia Patients." Australian and New Zealand Journal of Psychiatry 41:136-141.

Nicole , L., Abdel-Baki, A., Stip, E., et al. (2007). "L'Étude de Suivi des Psychoses Émergentes de l'Université de Montréal (ÉSPÉUM): contexte, buts et méthodologie." Santé Mentale au Québec XXXII(1): 317-331.

O'Connor, K., Stip, E., et al. (2007). "Treating Delusional Disorder: A Comparison of Cognitive-Behavioural Therapy and Attentional Placebo Control." The Canadian Journal of Psychiatry 52(3):182-190.

Potvin, S., Mancini-Marïe, A., Stip, E., et al. (2007). "Increased Striatal Gray Matter Densities in Patients with Schizophrenia and Substance Use Disorder: A Voxel-Based Morphometry Study." Psychiatry Research Neuroimaging 154:275-279.

Potvin, S., Mancini-Maeie, A., Fahim, C., Mensour, B., & Stip, E. (2007). Processing of social emotion in patients with schizophrenia and substance use disorder: An fMRI study. Social Neuroscience, 2(2), 106-116.

Potvin, S., Mancini-Marië, A., Stip, E., et al. (2007). "A fMRI Study of Social Emotion in Schizophrenia Patients With and Without Comorbid Substance Use Disorder." Social Neuroscience 2(2): 1-11.

Potvin, S., Sepehry, A., Stip, E., et al. (2007). "Comorbid Substance-Use in Schizophrenia: the File Drawer Effect." Schizophrenia Research 90 (1-3): 351-352.

Potvin, S., Sepehry, A., Stip, E., et al. (2007). "Meta-Analysis of Depressive Symptoms in Dual-Diagnosis Schizophrenia." Aust N Z J Psychiatry 41(10): 792-799.

Procyshyn, R., Wasan, K., Stip, E., et al. (2007). "Changes in Serum Lipids, Independent of Weight, are Associated with Changes in Symptoms during Long-Terme Clozapine Treatment." J Psychiatry Nerosci 32(5): 331-338.

Sepehry, A., Potvin, S., Stip, E., et al. (2007). "Selective Serotonin Reuptake Inhibitor (SSRI) Add-On Therapy for the Negative Symptoms of Schizophrenia: A Meta-Analysis." Journal of Clinical Psychiatry 69(4): 604-610.

Stip, E., Boyer, R., et al. (2007). "Sur la première ligne : Sondage pour un partage. Les omnipraticiens et la schizophrénie." Santé Mentale au Québec XXXII(1): 281-297.

Stip, E., Anselmo, K., (2007). "Effectiveness of Antipsychotics: Is the CATIE Trial a Tsunami?" Canadian Family Physician. 53:97-98.

Stip, E., Bergeron, T., et al. (2007). " Le Syndrome de Koro." Annales médico-psychologiques 165:147-153.

Stip, E., Corbière, M., et al. (2007). "Intrusion Errors in Explicit Memory: Their Differential Relationship with Clinical and Social Outcome in Chronic Schizophrenia." Cognitive Neuropsychiatry 12(2): 112-177.

Stip, E., Langlois, R., et al. (2007). "Fatal Agranulocytosis the Use of Olanzapine: in a Patient with Schizophrenia and Myelodysplasia." Progress in Neuropsychopharmacology & Biologicial psychiatry 31(1): 297-300.

Stip, E., Sablier, J., et al. (2007). "Cuisine et schizophrénie: activité carrefour d’une évaluation écologique, ergothérapeutique et neuropsychologique." Santé mentale au Québec. XXXII(1):159-179.

Stip, E., Sepehry, A., et al. (2007). "Add-On Therapy With Acetylcholinesterase Inhibitors for Memory Dysofunction in schizophrenia: A Systemic Quantitative Review, Part 2." Clinical Neuropharmacology 30(4): 218-229.