Sonia Lupien

Axe de recherche

• Signatures biologique, psychologique et sociale de la maladie mentale

Centre d'étude

Centre d'étude sur le stress humain

Affiliation universitaire (poste ou fonction)

Directrice scientifique, du centre de recherche Fernand-Seguin, Hôpital Louis-H Lafontaine, Université de Montréal

Directrice du Centre d'études sur le stress humain

Titulaire de la chaire en santé mentale des femmes et des hommes de l’Institut de santé des femmes et des hommes des Instituts de recherche en santé du canada (IRSC)

Professeure agrégée, Département de psychiatrie, Université de Montréal

Profil

Sonia Lupien s’intéresse aux effets du stress au cours d’une vie et a mené des études chez les enfants et les jeunes adultes. Ses études ont démontré que même les enfants sont vulnérables aux effets du stress, et que certains sécrètent des taux élévés d’hormones dès l’âge de 6 ans. Ses études chez les jeunes adultes l’ont menée à une découverte intéressante. Dans certaines conditions, des niveaux élevés de stress peuvent être bénéfiques. C’est une question d’équilibre : trop de stress peut être aussi nuisible que pas assez.
Sonia Lupien travaille désormais sur des façons de détecter et de prévenir les troubles reliés au stress chez les personnes de tous âges.

Pour en savoir plus sur ses travaux de recherche
Le stress chez les enfants: mythe ou réalite?

Prix et distinctions

• 2003 Nommée à titre de «Top 10 Canadians who make a difference» par la revue MacLean’s
• 2002 Prix «Canada’s Top 40 Under 40 Award»
• 2000 Nommée l’une des «50 jeunes personnalités les plus importantes de l'année 2000» par Radio-Canada (Le Point) et la revue Commerce
  

Publications récentes

Brenner, K., Liu, A., Laplante, D.P., Lupien, S., Pruessner, J.C., Ciampi, A., Joober, R., King, S. (2009) Cortisol response to a psychosocial stressor in schizophrenia: Blunted, delayed, or normal? Psychoneuroendocrinology, Feb. 3, Epub ahead of Print.

Fiocco, A. J., Poirier, J., Joober, R., Nair, N. P. V., & Lupien, S. J. (2008). Acute and long-term associations between ApoE genetic polymorphism, cortisol levels, and declarative memory performance in older adults. Psychoneuroendocrinology, 33(5), 625-633.

Hebert, S., & Lupien, S. J. (2009). Salivary cortisol levels, subjective stress, and tinnitus intensity in tinnitus sufferers during noise exposure in the laboratory. International Journal of Hygiene and Environmental Health, 212(1), 37-44. 

Lupien, S. J. (2009). Brains Under Stress. Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie, 54(1), 4-5.

Lupien, S.J., McEwen, B.S., Gunnar, M.R., Heim, C. (2009). Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Reviews - Neurosciences, Apr. 29, Epub ahead of print.

Pruessner, J., Dedovic, K., Pruessner, M., Lord, C., Buss, C., Collins, L., Dagher, A., Lupien S.J. (2009). Stress regulation in the central nervous system: evidence from structural and functional neuroimaging studies in human populations - 2008 Curt Richter Award Winner. Psychoneuroendocrinology, Apr 10. Epub ahead of print. - Pubmed. 

Lord, C., Buss, C., Lupien, S. J., & Pruessner, J. C. (2008). Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: A possible window of opportunity effect. Neurobiology of Aging, 29(1), 95-101.

Ouellet-Morin, I., Boivin, M., Dionne, G., Lupien, S. J., Arsenault, L., Barr, R. G., et al. (2008). Variations in heritability of cortisol reactivity to stress as a function of early familial adversity among 19-month-old twins. Archives of General Psychiatry, 65(2), 211-218.

Fiocco, A. J., Poirier, J., Joober, R., Nair, N. P. V., & Lupien, S. J. (2008). Acute and long-term associations between ApoE genetic polymorphism, cortisol levels, and declarative memory performance in older adults. Psychoneuroendocrinology, 33(5), 625-633.

Lord, C., Buss, C., Lupien, S. J., & Pruessner, J. C. (2008). Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: A possible window of opportunity effect. Neurobiology of Aging, 29(1), 95-101.

Ouellet-Morin, I., Boivin, M., Dionne, G., Lupien, S. J., Arsenault, L., Barr, R. G., et al. (2008). Variations in heritability of cortisol reactivity to stress as a function of early familial adversity among 19-month-old twins. Archives of General Psychiatry, 65(2), 211-218.

Pruessner, J. C., Dedovic, K., Lupien, S.J., et al. (2008). "Deactivation of the Limbic System during Acute Psychosocial Stress: Evidence from Positron Emission Tomography and Functional Magnetic Resonance Imaging Studies." Biological Psychiatry 63(2): 234-40.

Therrien, F., Drapeau, V., Lupien, S.J., et al. (2008). "Awakening Cortisol Response in Relation to Psychosocial Profiles and Eating Behaviors." Physiology & Behavior 93(1-2): 282-8.

Weekes, N. Y., Lewis, R. S., Goto, S. G., Garrison-Jakel, J., Patel, F., & Lupien, S. (2008). The effect of an environmental stressor on gender differences on the awakening cortisol response. Psychoneuroendocrinology, 33(6), 766-772.

Wrosch, C., Miller, G. E., Lupien, S., & Pruessner, J. C. (2008). Diurnal Cortisol Secretion and 2-Year Changes in Older Adults' Physical Symptoms: The Moderating Roles of Negative Affect and Sleep. Health Psychology, 27(6), 685-693.

Andrews, J., Wadiwalla, M., Lupien, S.J., et al. (2007). "Effects of Manipulating the Amount of Social-Evaluative Threat on the Cortisol Stress Response in Young Healthy Men." Behavioral Neuroscience 121(5): 871-6.

Buss, C., C. Lord, Lupien, S.J., et al. (2007). "Maternal Care Modulates the Relationship between Rrenatal Risk and Hippocampal Volume in Women but not in Men." Journal of Neuroscience 27(10): 2592-5.

Fiocco, A. J., R. Joober, Lupien, S.J., et al. (2007). "Education Modulates Cortisol Reactivity to the Trier Social Stress Test in Middle-Aged Adults." Psychoneuroendocrinology 32(8-10): 1158-63.

Hebert, S., Lupien, S.J. (2007). "The Sound of Stress: Blunted Cortisol Reactivity to Psychosocial Stress in Tinnitus Sufferers." Neuroscience Letters 411(2): 138-42.

Lupien, S. J., A. Evans, et al. (2007). "Hippocampal Volume is as Variable in Young as in Older Adults: Implications for the Notion of Hippocampal Atrophy in Humans." Neuroimage 34(2): 479-85.

Lupien, S. J., Maheu, F., et al. (2007). "The Effects of Stress and Stress Hormones on Human Cognition: Implications for the Field of Brain and Cognition." Brain & Cognition 65(3): 209-37.

Pruessner, M., Pruessner, J.C., Lupien, S.J., et al. (2007). "The Associations among Hippocampal Volume, Cortisol Reactivity, and Memory Performance in Healthy Young Men." Psychiatry Research 155(1): 1-10.

Fiocco, A. Wan, J.N., Lupien, S.J., et al. (2006). "Diurnal Cycle of Salivary Cortisol in Older Adult Men and Women with Subjective Complaints of Memory Deficits and/or Depressive Symptoms: Relation to Cognitive Functioning." Stress 9(3): 143-52.

Tu, M. T., Lupien, S.J., et al. (2006). "Diurnal Salivary Cortisol Levels in Postpartum Mothers as a Function of Infant Feeding Choice and Parity." Psychoneuroendocrinology 31(7): 812-24.

Tu, M. T., Lupien, S.J., et al. (2006). "Multiparity Reveals the Blunting Effect of Breastfeeding on Physiological Reactivity to Psychological Stress." Journal of Neuroendocrinology 18(7): 494-503.

Weekes, N., Lewis, R. Lupien, S.J., et al. (2006). "Examination Stress as an Ecological Inducer of Cortisol and Psychological Responses to Stress in Undergraduate Students." Stress 9(4): 199-206.

Dedovic, K., Renwick, R., Lupien, S.J., et al. (2005). "The Montreal Imaging Stress Task: Using Functional Imaging to Investigate the Effects of Perceiving and Processing Psychosocial Stress in the Human Brain." Journal of Psychiatry & Neuroscience 30(5): 319-25.

Hebert, S., Beland, R., Lupien, S.J., et al. (2005). "Physiological Stress Response to Video-Game Playing: the Contribution of Built-in Music." Life Sciences 76(20): 2371-80.

Lupien, S. J., Fiocco, A., et al. (2005). "Stress Hormones and Human Memory Function across the Lifespan." Psychoneuroendocrinology 30(3): 225-42.

Lupien, S. J., Schwartz, G., et al. (2005). "The Douglas Hospital Longitudinal Study of Normal and Pathological Aging: Summary of Findings." Journal of Psychiatry & Neuroscience 30(5): 328-34.

Maheu, F. S., Collicutt, P., Lupien, S.J., et al. (2005). "The Perfect Time to be Stressed: A Differential Modulation of Human Memory by Stress Applied in the Morning or in the Afternoon." Progress in Neuro-Psychopharmacology & Biological Psychiatry 29(8): 1281-8.

Maheu, F. S., Joober, R., Lupien, S.J., et al. (2005). "Declarative Memory After Stress in Humans: Differential Involvement of the Beta-Adrenergic and Corticosteroid Systems." Journal of Clinical Endocrinology & Metabolism 90(3): 1697-704.

Pruessner, J. C., Baldwin, M.W. Lupien, S.J., et al. (2005). "Self-Esteem, Locus of Control, Hippocampal Volume, and Cortisol Regulation in Young and Old Adulthood." Neuroimage 28(4): 815-26.