Pierre-Paul Rompré

Research areas

• Fundamental Research Unit

Academic profile

MA (psychology) School of Psychology, University of Ottawa (1981); PhD (psychology) School of Psychology, University of Ottawa (1984); Postdoctoral training (behavioral neuroscience) Dept Psychology, Concordia University (1985).

Research interests

Dr Rompré is a behavioral neuroscientist who uses freely-moving animals as well as electrophysiological techniques in the anesthetized rat to understand brain mechanisms important for normally (feeding, drinking) and abnormally (drug abuse) motivated behavior. In particular, his research aims to understand 1) the neural substrate(s) important for reward, 2) the effects of typical and atypical antipsychotic drugs on reward and their underlying mechanisms of action, and 3) how neurotensin produces sensitization to the behavioral effects of psychostimulant drugs.

Recents Publications

Marcangione, C., & Rompré, P. P. (2009). Topographical Fos induction within the ventral midbrain and projection sites following self-stimulation of the posterior mesencephalon. Neuroscience, 154(4), 1227-1241. Pubmed

Benaliouad, F., Kapur, S., Natesan, S., & Rompré, P. P. (2009). Effects of the dopamine stabilizer, OSU-6162, on brain stimulation reward and on quinpirole-induced changes in reward and locomotion. European Neuropsychopharmacology, 19(6), 416-430. Pubmed

Bourhis E, Maheux J, Paquet B, Kagechika H, Shudo K, Rompré PP, et coll. (2009) The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities. Psychopharmacology. Mar;202(4):635-48.

Levesque K, Lamarche C, Rompré PP. (2008) Evidence for a role of endogenous neurotensin in the development of sensitization to the locomotor stimulant effect of morphine. European Journal of Pharmacology. Oct;594(1-3):132-8.

Marcangione C, Rompré PP. (2008) Topographical Fos induction within the ventral midbrain and projection sites following self-stimulation of time posterior mesencephalon. Neuroscience.Jul;154(4):1227-41.

Benaliouad, F., Kapur, S., Rompré, P-P. (2007). "Blockade of 5-HT2a Receptors Reduces Haloperidol-Induced Attenuation of Reward." Neuropsychopharmacology 32: (551-561).
 
Potvin, S., A. Mancini-Marïe, Rompré, P-P, et al. (2007). "Increased Striatal Gray Matter Densities in Patients with  Schizophrenia and Substance Use Disorder: A Voxel-Based Morphometry Study." Psychiatry Research  Neuroimaging 154: 275-279.

Bauco, P., Rompré, P.P. (2006). "Cross-Fostering does not Alter the Differential Sensitivity of Fischer and Lewis Rats to Central Neurotensin-Induced Locomotion and Hypothermia." Behav Brain Res 171(1): 142-6.
 
Radja, F., P. Bauco, Rompré, P.P. (2006). "Effects of Excitotoxic Lesions of the Medial Prefrontal Cortex on Density of High Affinity [125I-Tyr3] Neurotensin Binding Sites Within the Ventral Midbrain and Striatum." Eur J Pharmacol. 539(3): 158-63.
 
Rompré, P.-P., Bauco, P. (2006). "Neurotensin Receptor Activation Sensitizes to the Locomotor Stimulant Effect of Cocaine: a Role for NMDA Receptors." Brain Res 1085(1): 77-86.

Blackburn, A., Dewar, K., Rompré, P-P., et al. (2004). "Excitotoxic Lesions of the Prefrontal Cortex Attenuate the Potentiation of Amphetamine-Induced Locomotion by Repeated  Neurotensin Receptor Activation." Brain Res 998: 184-193.

Rompré, P.-P., Stip, E., et al. (2004). "Neurobiology of Severe Mental Disorders :  from Cell to Bedside.  25th International Symposium of the Centre de recherche en Sciences Neurologiques, Université de Montréal " J. Psychiatry Neurosci 29(3): 167-169.

St-Gelais, F., Legault, M., Rompré, P-P., et al. (2004). "Role of Calcium in Neurotensin-Evoked Enhancement in Firing in Mesencephalic Dopamine Neurons." Journal of Neuroscience 24(10): 2566-2574.  

Bauco, P., Rompré, P-P. (2003). "Central Neurotensin Receptor Activation produces Differential Behavioral Responses in Fischer and Lewis Rats." Psychopharmacology 168: 253-261.
 
Bauco, P., Rompré, P-P. (2003). "Differential Sensitivity to Neurotensin-Induced Hypothermia, but not Analgesia, in Fischer 344 and Lewis Rats." Peptides 24: 1189-1194.